Digital transformation is ongoing in many areas of today’s society, which will impact many aspects of people’s lives via means such as smart cities, robotics, transportation, and next-generation industries. At the same time, the current centralized cloud infrastructure is not adequate to serve the transformation’s requirements. We believe that three technologies can come together to shape a new secure service and application platform: 5G, edge-centric compute, and artificial intelligence. In this context, European industry has a good position in 5G networks, transportation and industrial applications, but needs to strengthen the position in secure cloud, data centre and artificial intelligence technologies to be at the forefront of development.The primary focus of the AI-NET-PROTECT sub-project is to provide automated resilience and secure networks operated on trusted equipment to critical infrastructures and enterprises. AI-NET-PROTECT will ensure the protection of critical data, network performance (like latency, throughput, availability), and infrastructure (against tampering and attacks). To achieve these objectives, the project will develop a scalable network and node architecture to address the diverse KPIs by a mix of open and purpose build hardware and software including whiteboxes. Network telemetry and intent-based software-defined network management and control will provide zero-touch provisioning and support artificial intelligence based automation of end-to-end services. Strong security based on multi-layer cryptography, agile crypt-functions, and quantum-safe algorithms will form an integral part for the developed architecture. The key use cases for AI are performance optimization, proactive fault and anomaly detection, penetration and vulnerability testing, and security incident management.